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Although the single most significant risk factor for developing Alzheimer's disease (AD) is age, the mechanisms underlying the transition from normal aging to AD are not well understood. One hypothesized mechanism for this transition is the loss of white matter (WM) integrity. The overall hypothesis of this project is that an accelerated loss of WM integrity is evident in the transition from normal aging to AD, and by combining biomarkers of WM integrity, degree of Aβ accumulation, neurodegeneration, and cognitive function, we will be able to stratify cognitively intact older adults for risk of conversion to AD.
5R01AG054159-07 |
